منابع مشابه
Striatin-dependent membrane estrogen receptor signaling and vasoprotection by estrogens.
It is well known that cardiovascular disease is less frequent in premenopausal women compared with men but rises rapidly in postmenopausal women. Such early observations led to the hypothesis that estrogen therapy will reduce the risk of postmenopausal women developing cardiovascular disease.1 However, observational studies have led to conflicting results, with some studies reporting reductions...
متن کاملGPER mediates activation of HIF1α/VEGF signaling by estrogens.
Biological responses to estrogens in normal and malignant tissues are mainly mediated by the estrogen receptors ERα and ERβ, which function as ligand-activated transcription factors. In addition, the G protein-coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (CAF) that contribute to cancer progression. In this study, we evaluat...
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Postmenopausal women have an elevated risk of developing a neurodegenerative disease. These clinical observation supported by basic research, suggest that estrogens are neuroprotective. Insulin resistance represents an independent factor in the etiology of age-associated disease and metabolic syndrome should be considered as a contributing factor to the higher post-menopausal vulnerability to n...
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Hormones and nitric oxide (NO), a free radical, are ancestral molecules, conserved through evolution, that modulate many aspects of the physiology and pathophysiology of living organisms by regulating transcription of genes involved in development, metabolism, and differentiation. Of interest, both estrogen and NO signaling, specifically through the estrogen receptor-alpha (ERalpha) and the end...
متن کاملMolecular and Cellular Pathobiology GPER Mediates Activation of HIF1a/VEGF Signaling by Estrogens
Biological responses to estrogens in normal and malignant tissues are mainly mediated by the estrogen receptors ERa and ERb, which function as ligand-activated transcription factors. In addition, the G protein– coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (CAF) that contribute to cancer progression. In this study, we evalua...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2007
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.21253